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Home > Problems > Chapter 5
8. This problem explores the information content of a scoring matrix by the relative entropy method (ignores background frequencies). Read the notes on information content of sequences on page 213 before trying this problem.
- Calculate the entropy or uncertainty (Hc) for each column and for the entire matrix.
- Calculate the decrease in uncertainty or amount of information (Rc) for column 1 due to these data (for DNA, Rc = 2 – Hc and for proteins, Rc = 4.32 – Hc).
- Calculate the amount that the uncertainty is reduced (or the amount of information contributed) for each base in column 1.
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