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2. Another useful NCBI search tool is LocusLink, which can be used to search for information on genes and proteins based on the known location of the genes on chromosomes that have been sequenced. Eventually Entrez and LocusLink will probably be combined at NCBI to create an even more powerful search machine. We will retrieve information about the HSF1 protein using LocusLink.
  1. Go to NCBI LocusLink address given above. In the first box choose LocusLink, then Brief in the second, and Human as the search organism in the third. Then enter HSF1 as the query and click GO. A small number of entries match the query and one of them should be HSF1. The position column shows the relative numbered position on the long arm (q for the long arm) of chromosome 8. The colored boxes provide sequence of the gene with direct links to RefSeq. Clicking on the green P will give the protein sequence entries of the protein including the RefSeq sequence labeled NP.
  2. Click on the empty box beside the sequence and then click view to produce a page with a great deal of information about the gene, including gene structure, genome location, RefSeq protein, and nucleic acid sequence identifiers, and much useful information about the evidence on which the gene sequence is based. Click on OMIM (Online Inheritance in Man) to see a biological summary of the HSF1 gene functions.


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